E2f3 13557

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Gene ID: 13557
Gene symbol: e2f3
Gene Description: e2f transcription factor 3
Aliases: E2f3a; E2F3b; mKIAA0075
Human Ortholog Gene ID: [1871]
Reviewer Judgement: TF Gene Candidate
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Transcription Factor Family
Homolog Cluster(s): 104394

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15448153] Co-activation Mouse Medium EMSA with whole cell extracts from keratinocytes shows E2F associated with DP binds to an oligonucleotide probe corresponding to the E2F-binding site in the dihydrofolate reductase promoter. Amy Ticoll
[17135268] DNA Binding Human Medium ChIP in HEK-293 cells indicate E2F3 is associated with the miR-17�92 promoter. Experiments conducted with appropriate controls. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA shows E2F associated with DP binds to the E2F-binding site in the dihydrofolate reductase promoter. ChIP indicates E2F3 is associated with the miR-17–92 promoter. Transfection assays required to confirm TF Gene status.


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Facts about E2f3 13557RDF feed
Gene description e2f transcription factor 3  +
Gene id 13,557  +
Gene judgment TF Gene Candidate  +
Gene symbol e2f3  +, E2f3a  +, E2F3b  +, and mKIAA0075  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,394  +
Protein family 1.2 Winged Helix-Turn-Helix/15 Transcription Factor Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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