E2f4 104394

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Gene ID: 104394
Gene symbol: e2f4
Gene Description: e2f transcription factor 4
Aliases: 2010111M04Rik; AI427446
Human Ortholog Gene ID: [1874]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Transcription Factor Family
Homolog Cluster(s): 104394

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12110166] DNA Binding; Transactivation Mouse Strong EMSA assays show that E2F4 can bind to the Pparg1 promoter and luciferase reporter assays using the Pparg1 promoter show that E2F4 can transactivate this promoter. Sarav Sundararajan
Additional Reviewer Comments:
Reviewer: Sarav Sundararajan

In addition to its role as a sequence-specific transcription factor, this protein can also bind to Smad3 and function as a cofactor, contributing as a repressor.


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Facts about E2f4 104394RDF feed
Gene description e2f transcription factor 4  +
Gene id 104,394  +
Gene judgment TF Gene  +
Gene symbol e2f4  +, 2010111M04Rik  +, and AI427446  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 104,394  +
Protein family 1.2 Winged Helix-Turn-Helix/15 Transcription Factor Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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