E2f6 50496

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Gene ID: 50496
Gene symbol: e2f6
Gene Description: e2f transcription factor 6
Aliases: AI462434; E2F6b; EMA
Human Ortholog Gene ID: [1876]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Transcription Factor Family
Homolog Cluster(s): 104394

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15574595] DNA Binding Human Strong ChIP assays in human neuroblastoma (T98G) cells indicate E2F6 associates specifically with the E2F target genes activated at G1/S. Amy Ticoll
[15936277] DNA Binding Human Medium Affinity chromatography with covalently coupled DNA oligonucleotides to sepharose using extracts from HEK293 cells indicates specific interaction of E2F6 with a wt E2F site. EMSAs performed with whole-cell extracts from HeLa cells confirm the interaction. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

ChIP assays in human neuroblastoma (T98G) cells indicate E2F6 associates specifically with the E2F target genes activated at G1/S. Inhibition of E2F6 activity results in specific derepression during S phase. EMSAs show E2F6 specifically binds a wt E2F site.


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Facts about E2f6 50496RDF feed
Gene description e2f transcription factor 6  +
Gene id 50,496  +
Gene judgment TF Gene  +
Gene symbol e2f6  +, AI462434  +, E2F6b  +, and EMA  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,394  +
Protein family 1.2 Winged Helix-Turn-Helix/15 Transcription Factor Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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