E2f7 52679

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Gene ID: 52679
Gene symbol: e2f7
Gene Description: e2f transcription factor 7
Aliases: A630014C11Rik; D10Ertd739e
Human Ortholog Gene ID: [144455]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Transcription Factor Family
Homolog Cluster(s): 104394

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12893818] DNA Binding; Transactivation Mouse Not Selected EMSA experiments showed that recombinant murine E2F7 binds E2F recognition sites in the DHFR, proliferating cell nuclear antigen, and E2 promoters in mouse embryonic fibroblasts (MEFs). In transient cotransfections of MEFs, recombinant murine E2F7 repressed the activation of luciferase reporter constructs carrying a variety of E2F-responsive promoters, including TK, E2F2, E2F3a, polymerase-alpha, and Rb. Magdalena Swanson
[14633988] DNA Binding Human Strong EMSA experiments using U2OS cell extracts showed that recombinant human E2F7 binds specifically to wild-type and not mutant E2F binding sites on oligonucleotides. Magdalena Swanson
Additional Reviewer Comments:
Reviewer: Magdalena Swanson

E2f7 is a TF. Recombinant E2F7 specifically binds E2F recognition sites in synthesized oligonucleotides and the DHFR, proliferating cell nuclear antigen, and E2 promoters in EMSA experiments. The recombinant protein represses activation of luciferase reporter constructs that contain E2F-responsive promoters in transient cotransfection studies.


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Facts about E2f7 52679RDF feed
Gene description e2f transcription factor 7  +
Gene id 52,679  +
Gene judgment TF Gene  +
Gene symbol e2f7  +, A630014C11Rik  +, and D10Ertd739e  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,394  +
Protein family 1.2 Winged Helix-Turn-Helix/15 Transcription Factor Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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