Eg627232 627232

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Gene ID: 627232
Gene symbol: eg627232
Gene Description: predicted gene, eg627232
Aliases:
Human Ortholog Gene ID:
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 627232

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10786636] TF PPI Rat Strong NRBF-2 is identified by yeast 2-hybrid screening as interacting partner of PPAR alpha and other NRs. Transfection of yeast cells with the fusion protein of NRBF-2 with the yeast GAL4 DNA binding domain leads to reporter activation. Andrew Kwon
[15610520] TF PPI Human Strong Yeast 2 hybrid screen using the ligand-binding domain of human PPAR-alpha shows that COPR1 interacts with PPAR-alpha. COPR2 is an alternative splice variant of COPR1 and homologue of rat NRBF-2. Fusion products of COPR1 and COPR2 and their truncated versions with GAL4-DNA binding domain shows the presence of auto-activation domain. COPR1:PPAR interactions yield much higher reporter expression than COPR2:PPAR. Mutation of NR box on COPR1/COPR2 leads to decrease in reporter activity. Mutation of the AF-2 region of RXRalpha leads to decrease in reporter activity in yeast, which is also supported by mammlian two-hybrid studies. COPR1/COPR2 partially represses RXR activity in HaCaT cells. Andrew Kwon
Additional Reviewer Comments:
Reviewer: Andrew Kwon

NRBF-2 is a co-transcription factor, which binds to NR via its NR box, which interacts with the AF-2 region of NR, as shown by yeast 2-hybrid assays and mutation studies.


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Facts about Eg627232 627232RDF feed
Gene description predicted gene, eg627232  +
Gene id 627,232  +
Gene judgment TF Gene  +
Gene symbol eg627232  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 627,232  +
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