Egr1 13653

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Gene ID: 13653
Gene symbol: egr1
Gene Description: early growth response 1
Aliases: A530045N19Rik; egr; Egr-1; ETR103; Krox-1; Krox-24; Krox24; NGF1-A; NGFI-A; NGFIA; TIS8; Zenk; Zfp-6; Zif268
Human Ortholog Gene ID: [1958]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / BetaBetaAlpha-zinc finger Family
Homolog Cluster(s): 107586

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8336701] DNA Binding; Transactivation Unknown Strong The Egr-1 gene product transactivates a synthetic promoter construct in transient-transfection assays. the structure and function of the Egr-1 protein are analysed in detail, delineating independent and modular activation, repression, DNA-binding, and nuclear localization activities. David Martin
[9858508] DNA Binding Human; Mouse Strong The binding of a recombinant Egr-1 produced a DNA-protein complex is studied by Electrophoretic Mobility Shift Assays. The specificity of Egr-1 binding was demonstrated by a competition assay using an excess of an oligonucleotide carrying an Egr-1 binding site and by the decreased mobility of the complex upon the addition of an Egr-1-specific antibody. David Martin
[10049687] Transactivation Human; Mouse Strong An Egr-1 mutant comprising the entire C-terminal activation domain and partly truncated DNA-binding and nuclear translocation domains function as the transdominant repressor of Egr-1-dependent gene transcription (luciferase reported plasmid). David Martin
Additional Reviewer Comments:


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Facts about Egr1 13653RDF feed
Gene description early growth response 1  +
Gene id 13,653  +
Gene judgment TF Gene  +
Gene symbol egr1  +, A530045N19Rik  +, egr  +, Egr-1  +, ETR103  +, Krox-1  +, Krox-24  +, Krox24  +, NGF1-A  +, NGFI-A  +, NGFIA  +, TIS8  +, Zenk  +, Zfp-6  +, and Zif268  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,586  +
Protein family 2.1 Zinc-coordinating Group/17 BetaBetaAlpha-zinc finger Family  +
Protein group 2.1 Zinc-coordinating Group   +
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