Egr2 13654

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Gene ID: 13654
Gene symbol: egr2
Gene Description: early growth response 2
Aliases: Egr-2; Krox-20; Krox20; NGF1-B; Zfp-25; Zfp-6
Human Ortholog Gene ID: [1959]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / BetaBetaAlpha-zinc finger Family
Homolog Cluster(s): 107586


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12687019] DNA Binding Human Medium EMSA with extracts from infected SW480 cells indicates EGR2 binds to specific sites within the BNIP3L and BAK promoter regions. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA indicates EGR2 binds to specific sites within the BNIP3L and BAK promoter regions. Reporter assays with subcloning into pGL3-basic vector show EGR2 activates BNIP3L and BAK.

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Facts about Egr2 13654RDF feed
Gene description early growth response 2  +
Gene id 13,654  +
Gene judgment TF Gene  +
Gene symbol egr2  +, Egr-2  +, Krox-20  +, Krox20  +, NGF1-B  +, Zfp-25  +, and Zfp-6  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,586  +
Protein family 2.1 Zinc-coordinating Group/17 BetaBetaAlpha-zinc finger Family  +
Protein group 2.1 Zinc-coordinating Group   +
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