Egr4 13656

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Gene ID: 13656
Gene symbol: egr4
Gene Description: early growth response 4
Aliases: NGF1-C; NGFI-C; NGFIC; pAT133
Human Ortholog Gene ID: [1961]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / BetaBetaAlpha-zinc finger Family
Homolog Cluster(s): 107586

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[17192429] DNA Binding Mouse Strong EMSAs using nuclear extracts of transfected N2a cells indicates Egr4 protein specifically binds to the Egr4KCC2 element in vitro. Transfection assays indicates disruption of the Egr4KCC2 site decreases Egr4-mediated induction of the KCC2 promoter. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA shows the Egr4 protein specifically binds to the Egr4KCC2 element in vitro. Transfection assays indicate the Egr4KCC2 element is sufficient for Egr4-mediated induction of the KCC2 promoter.


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Facts about Egr4 13656RDF feed
Gene description early growth response 4  +
Gene id 13,656  +
Gene judgment TF Gene  +
Gene symbol egr4  +, NGF1-C  +, NGFI-C  +, NGFIC  +, and pAT133  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,586  +
Protein family 2.1 Zinc-coordinating Group/17 BetaBetaAlpha-zinc finger Family  +
Protein group 2.1 Zinc-coordinating Group   +
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