Ehf 13661

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Gene ID: 13661
Gene symbol: ehf
Gene Description: ets homologous factor
Aliases: 9030625L19Rik; AU019492
Human Ortholog Gene ID: [26298]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Ets Domain Family
Homolog Cluster(s): 104156


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10644770] DNA Binding Human Strong ESE-3 binds to Ets binding sites in the c-MET promoter and in the promoters of a number of glandular epithelium-specific genes as shown by EMSAs. Experiments performed with in vitro translated ESE-3b and ESE3a. Amy Ticoll
[17027647] DNA Binding Human Medium EMSA indicates ESE-3 (Ehf) binds a specific region of the DR-5 promoter. Experiments conducted with appropriate controls. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSAs show ESE-3 (Ehf) binds to Ets binding sites in the DR-5 and c-MET promoters. Transient transfection of ESE-3 significantly increases DR-5 and c-MET levels.

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Facts about Ehf 13661RDF feed
Gene description ets homologous factor  +
Gene id 13,661  +
Gene judgment TF Gene  +
Gene symbol ehf  +, 9030625L19Rik  +, and AU019492  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,156  +
Protein family 1.2 Winged Helix-Turn-Helix/16 Ets Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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