Eid1 58521

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Gene ID: 58521
Gene symbol: eid1
Gene Description: ep300 interacting inhibitor of differentiation 1
Aliases: 2610002K20Rik; Cri1; EID-1; ORF12; PNAS-22; PTD014
Human Ortholog Gene ID: [23741]
Reviewer Judgement: TF Gene Candidate
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 58521

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11964378] Co-activation Mouse Strong Cri1 (EID-1) was cloned by two-hybrid assay using the mouse SHP (short heterodimeric partner).

Bacterially expressed GST-Cri1 interacts with histone H2A, H2B, H3 and H4 as well as the histone acetyltransferases CBP/p300 and GCN5 in GST-pulldown assays. Full length Cri1 binds GST-H4 (but not GST fusion proteins containing H2A, H2B or H3) in similar assays.

Cri1 inhibits the CBP/p300-dependent transactivation of the TIf2 and RAP250 coactivator proteins measured following transient cotransfections performed in COS-7 cells.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Cri1 (EID-1) was cloned by two-hybrid assay using the mouse SHP (short heterodimeric partner). Bacterially expressed GST-Cri1 interacts with histone H2A, H2B, H3 and H4 as well as the histone acetyltransferases CBP/p300 and GCN5 in GST-pulldown assays. Full length Cri1 binds GST-H4 (but not GST fusion proteins containing H2A, H2B or H3) in similar assays. Cri1 inhibits the CBP/p300-dependent transactivation of the TIf2 and RAP250 coactivator proteins measured following transient cotransfections performed in COS-7 cells.


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Facts about Eid1 58521RDF feed
Gene description ep300 interacting inhibitor of differentiation 1  +
Gene id 58,521  +
Gene judgment TF Gene Candidate  +
Gene symbol eid1  +, 2610002K20Rik  +, Cri1  +, EID-1  +, ORF12  +, PNAS-22  +, and PTD014  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 58,521  +
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