Elf1 13709

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Gene ID: 13709
Gene symbol: elf1
Gene Description: e74-like factor 1
Aliases: Elf-1; mElf-1; p70; Sts1
Human Ortholog Gene ID: [1997]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Ets Domain Family
Homolog Cluster(s): 104156

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12065417] DNA Binding; TF PPI Mouse Strong E74-like factor 1 binds to a SCL stem cell enhancer (EMSA, chIP).

It forms an enhanceosome with GATA-2 and Fli-1 on this enhancer as shown by the EMSA and GST pull-down experiments.

Elodie Portales-Casamar
[16002702] DNA Binding Mouse Strong Gel shift assays and chromatin immunoprecipitation experiments showed that E74-like factor 1 binds to the CD1D1 promoter. Elodie Portales-Casamar
Additional Reviewer Comments:
Reviewer: Elodie Portales-Casamar

specific DNA binding is shown with multiple experiment in different genes for this factor. No direct transactivation is shown.


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Facts about Elf1 13709RDF feed
Gene description e74-like factor 1  +
Gene id 13,709  +
Gene judgment TF Gene  +
Gene symbol elf1  +, Elf-1  +, mElf-1  +, p70  +, and Sts1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,156  +
Protein family 1.2 Winged Helix-Turn-Helix/16 Ets Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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