Elf3 13710

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Gene ID: 13710
Gene symbol: elf3
Gene Description: e74-like factor 3
Aliases: ESE-1; ESX; jen
Human Ortholog Gene ID: [1999]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Ets Domain Family
Homolog Cluster(s): 104156

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11893733] DNA Binding; Transactivation Mouse Strong Elf3 in nuclear extracts of transfected HeLa cells binds to oligonucleotide probes prepared from the murine TGFbeta R-II promoter (bp +3 to +34) in gel shift assays. Participation of Elf3 in the retarded complex was confirmed by antibody supershift. Chromatin immunoprecipitation studies showed that Elf3 bound to the mTGFbeta R-II promoter in vivo.

Elf3 transactivates the mTGFbeta R-II promoter following transient transfection in human embryonal kidnet 293T cells and retinoic acid differentiated F9 embryonal carcinoma cells.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Elf3 in nuclear extracts of transfected HeLa cells binds to oligonucleotide probes prepared from the murine TGFbeta R-II promoter (bp +3 to +34) in gel shift assays. Participation of Elf3 in the retarded complex was confirmed by antibody supershift. Chromatin immunoprecipitation studies showed that Elf3 bound to the mTGFbeta R-II promoter in vivo. Elf3 transactivates the mTGFbeta R-II promoter following transient transfection in human embryonal kidnet 293T cells and retinoic acid differentiated F9 embryonal carcinoma cells.


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Facts about Elf3 13710RDF feed
Gene description e74-like factor 3  +
Gene id 13,710  +
Gene judgment TF Gene  +
Gene symbol elf3  +, ESE-1  +, ESX  +, and jen  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,156  +
Protein family 1.2 Winged Helix-Turn-Helix/16 Ets Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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