En1 13798

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Gene ID: 13798
Gene symbol: en1
Gene Description: engrailed 1
Aliases: En-1; Mo-en.1
Human Ortholog Gene ID: [2019]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8096059] DNA Binding Mouse Medium EMSAs indicate En-1 binds specifically to a consensus site containing (C/G)TAATTG. Amy Ticoll
[10504454] TF PPI Mouse Medium En-1 binds to in vitro translated DNA-binding transcription factor Pax6 in a GST pull-down assay. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSAs indicate En-1 binds specifically to a consensus site. En-1 binds to in vitro translated DNA-binding transcription factor Pax6 in a GST pull-down assay. Engrailed-1 is found to negatively regulate β-Catenin transcriptional activity.


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Facts about En1 13798RDF feed
Gene description engrailed 1  +
Gene id 13,798  +
Gene judgment TF Gene  +
Gene symbol en1  +, En-1  +, and Mo-en.1  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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