En2 13799

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Gene ID: 13799
Gene symbol: en2
Gene Description: engrailed 2
Aliases: BB131122; En-2
Human Ortholog Gene ID: [2020]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9813123] Co-activation Mouse Medium GST pull-down assay indicates En2 directly binds Foxa2. EMSA using nuclear extracts from mouse neonatal (P0) cerebellum and posterior mesencephalon indicates Foxa2 inhibits En2{delta}SP (shorter version of En2) binding to the HF1 and HF2 sites of MAP1B promoter. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

GST pull-down assay indicates En2 directly binds Foxa2. EMSA indicates Foxa2 inhibits En2{delta}SP (shorter version of En2) binding to the HF1 and HF2 sites of MAP1B promoter. Luciferase reporter assays indicate Foxa2 and En2 jointly regulate the MAP1B promoter.


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Facts about En2 13799RDF feed
Gene description engrailed 2  +
Gene id 13,799  +
Gene judgment TF Gene  +
Gene symbol en2  +, BB131122  +, and En-2  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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