Eomes 13813

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Gene ID: 13813
Gene symbol: eomes
Gene Description: eomesodermin homolog (xenopus laevis)
Aliases: C77258; Tbr2
Human Ortholog Gene ID: [8320]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Beta-Hairpin-Ribbon Group
DBD Protein Group/Family Classification: Beta-Hairpin-Ribbon Group / Transcription Factor T-Domain
Homolog Cluster(s): 13813

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8978604] Transactivation Other Not Selected Ectopic expression of Eomes in animal caps induces the transcription of nearly all mesodermal genes in a concentration-dependent way. Overexpression of Eomes dorsalizes ventral mesoderm, inducing gsc and changing cell fate to muscle and notochord. Blocking the function of Eomes causes gastrulation arrest and defective mesoderm-dependent gene activation. We propose that Eomes fulfills an essential function in initiating mesoderm differentiation and in determining mesodermal cell fate. Gwenael Breard
[11585801] DNA Binding Other Strong Members of the T box family of transcription factors play important roles in early development. Different members of the family exert different effects and here the authors show that much of the specificity of the Xenopus T box proteins Xbra, VegT and Eomesodermin resides in the DNA-binding domain, or T box. Binding site selection experiments show that the three proteins bind the same core sequence, but they select paired sites that differ in their orientation and spacing Gwenael Breard
Additional Reviewer Comments:
Reviewer: Gwenael Breard

Eomes is a key T-box containing transcription factor involved in initiating mesoderm differentiation and in determining mesodermal cell fate.


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Facts about Eomes 13813RDF feed
Gene description eomesodermin homolog (xenopus laevis)  +
Gene id 13,813  +
Gene judgment TF Gene  +
Gene symbol eomes  +, C77258  +, and Tbr2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 13,813  +
Protein family 6 Beta-Hairpin-Ribbon Group/34 Transcription Factor T-Domain  +
Protein group 6 Beta-Hairpin-Ribbon Group   +
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