Epas1 13819

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Gene ID: 13819
Gene symbol: epas1
Gene Description: endothelial pas domain protein 1
Aliases: HIF-2alpha; HLF; HRF; MOP2
Human Ortholog Gene ID: [2034]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding;

DNA-Binding: sequence-specific

DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11622

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15190133] Co-activation; DNA Binding Unknown Strong EPAS1 and ARNT bind DNA as a heterodimer; transactivation Jared Roach
Additional Reviewer Comments:
Reviewer: Jared Roach

From OMIM: "Members of the bHLH-PAS family are transcription factors that contain a bHLH DNA-recognition motif and a PAS domain composed of 2 imperfect repeats." The human and mouse canonical genes have a NCBI "Conserved Domain" predicted HLH binding domain.


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Facts about Epas1 13819RDF feed
Gene description endothelial pas domain protein 1  +
Gene id 13,819  +
Gene judgment TF Gene  +
Gene symbol epas1  +, HIF-2alpha  +, HLF  +, HRF  +, and MOP2  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +, and DNA-Binding: sequence-specific  +
Homolog cluster 11,622  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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