Esr1 13982

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Gene ID: 13982
Gene symbol: esr1
Gene Description: estrogen receptor 1 (alpha)
Aliases: AA420328; AU041214; ER-alpha; ERa; ERalpha; [[gene_symbol:=ER[a]|ER[a]]]; ESR; Estr; Estra; Nr3a1
Human Ortholog Gene ID: [2099]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10908317] DNA Binding Human Medium In vitro translated Esr1 binds the EREc oligomer in gel shift assays. Amy Ticoll
[16636675] Non-specific DNA Human Medium ChIP assays performed on MCF7-pcBARX2 cells indicate ESR1 binds to alternative ESR1 gene promoters. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Esr1 binds the EREc oligomer in gel shift assays. ChIP assays indicate ESR1 binds to alternative ESR1 gene promoters. Esr1 activates trans­cription in reporter assays in the yeast strain BJ2168.


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Facts about Esr1 13982RDF feed
Gene description estrogen receptor 1 (alpha)  +
Gene id 13,982  +
Gene judgment TF Gene  +
Gene symbol esr1  +, AA420328  +, AU041214  +, ER-alpha  +, ERa  +, ERalpha  +, ESR  +, Estr  +, Estra  +, and Nr3a1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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