Esr2 13983

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Gene ID: 13983
Gene symbol: esr2
Gene Description: estrogen receptor 2 (beta)
Aliases: ERbeta; [[gene_symbol:=ER[b]|ER[b]]]; Estrb
Human Ortholog Gene ID: [2100]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9058381] Transactivation Mouse Medium Mouse ER beta transactivates promoters containing synthetic or natural estrogen response elements in an estradiol (E2)-dependent manner. Amy Ticoll
[12047722] DNA Binding Human Medium In vitro translated ER-beta binds specifically to the ERE of the A2 gene promoter. Experiments conducted with appropriate controls. Amy Ticoll
[16484337] DNA Binding Human Strong CHIP assays in HeLa cells indicate ER-beta binds to the MAO-B promoter at selective AGGTCA motifs. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

ER-beta (Esr2) binds specifically to regions of the A2 and MAO-B gene promoters, as indicated by EMSA and CHIP assays. ER beta transactivates promoters containing synthetic or natural estrogen response elements.


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Facts about Esr2 13983RDF feed
Gene description estrogen receptor 2 (beta)  +
Gene id 13,983  +
Gene judgment TF Gene  +
Gene symbol esr2  +, ERbeta  +, and Estrb  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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