Esrrb 26380

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Gene ID: 26380
Gene symbol: esrrb
Gene Description: estrogen related receptor, beta
Aliases: Err2; ERRb; Estrrb; Nr3b2
Human Ortholog Gene ID: [2103]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8626619] Co-activation Human Weak Transient transfection assays reveal transcriptional activity mediated by GR is strongly suppressed by coexpression of ERR2 (Esrrb). Amy Ticoll
[15766247] DNA Binding Human Medium Expressed, purified, and refolded ERR2 (Esrrb) DBD binds a specific DNA sequence in EMSA and DNase footprint assays. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

ERR2 (Esrrb) binds a specific DNA sequence in EMSA and DNase footprint assays. Transient transfection assays reveal transcriptional activity mediated by GR is strongly suppressed by coexpression of ERR2.


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Facts about Esrrb 26380RDF feed
Gene description estrogen related receptor, beta  +
Gene id 26,380  +
Gene judgment TF Gene  +
Gene symbol esrrb  +, Err2  +, ERRb  +, Estrrb  +, and Nr3b2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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