Esrrg 26381

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Gene ID: 26381
Gene symbol: esrrg
Gene Description: estrogen-related receptor gamma
Aliases: ERR3; Errg; mKIAA0832; NR3B3
Human Ortholog Gene ID: [2104]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15149736] DNA Binding; Transactivation Human; Mouse Strong Cotransfection of HeLa, SaOs-2, and U2-OS cells with ERR expression plasmids and reporter genes driven either by three ERR response elements or two estrogen response elements demonsrate that ERRγ activates both reporter genes efficiently in all three cell lines used.

ERRγ DNA-binding ability and activation function-2 are required for ERE- and ERRE-dependent transactivation is demonstrated by mutational analysis of ERRgamma, ERR element reporter genes and EMSA/supershifts.

Debra Fulton
Additional Reviewer Comments:
Reviewer: Debra Fulton

Errg is a transcription factor. It binds DNA by EMSA and activates ERR element- and estrogen response element - reporter genes.


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Facts about Esrrg 26381RDF feed
Gene description estrogen-related receptor gamma  +
Gene id 26,381  +
Gene judgment TF Gene  +
Gene symbol esrrg  +, ERR3  +, Errg  +, mKIAA0832  +, and NR3B3  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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