Ets1 23871

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Gene ID: 23871
Gene symbol: ets1
Gene Description: e26 avian leukemia oncogene 1, 5' domain
Aliases: AI196000; AI448617; D230050P06; Ets-1; MGC130355; MGC18571; Tpl1
Human Ortholog Gene ID: [2113]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: non-sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Ets Domain Family
Homolog Cluster(s): 104156

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12119294] DNA Binding; Transactivation Mouse Strong Ets-1 binds an EBS element in the SERCA3 promoter. Ets-1 and Sp1 factors interact directly with each other on the SERCA3 promoter (Affinity purification of DNA-binding proteins with 5'-Biotinylated oligonucleotides in EA.hy926 or MoBr 204 cells).

Ets-1 is able to transactivate the SERCA3 promoter in MoBr 204 cells (gene reporter assay). Ets-1 induces the expression of SERCA3 in MoBr 204 cells (RT-PCR analysis of expression of SERCA3 performed on cells trqnsfected with Ets-1).

Elodie Portales-Casamar
Additional Reviewer Comments:
Reviewer: Elodie Portales-Casamar

The Ets-1 TF as been well characterized and a lot of its gene targets are known.


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Facts about Ets1 23871RDF feed
Gene description e26 avian leukemia oncogene 1, 5' domain  +
Gene id 23,871  +
Gene judgment TF Gene  +
Gene symbol ets1  +, AI196000  +, AI448617  +, D230050P06  +, Ets-1  +, MGC130355  +, MGC18571  +, and Tpl1  +
Gene taxonomy DNA-Binding: non-sequence-specific  +
Homolog cluster 104,156  +
Protein family 1.2 Winged Helix-Turn-Helix/16 Ets Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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