Ets2 23872

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Gene ID: 23872
Gene symbol: ets2
Gene Description: e26 avian leukemia oncogene 2, 3' domain
Aliases: AU022856; Ets-2
Human Ortholog Gene ID: [2114]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Ets Domain Family
Homolog Cluster(s): 104156

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12637547] DNA Binding Human Medium EMSA indicates Ets-2 binds to a specific region within the BRCA1 promoter. Amy Ticoll
[12928043] DNA Binding Human Medium Ets2 binds to a specific region within the human presenilin 1 promoter in yeast one-hybrid assays. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSA indicates Ets-2 binds to a specific region within the BRCA1 promoter. Transient transfections performed in MCF-7 cells suggest Ets-2 represses BRCA1 promoter activity.


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Facts about Ets2 23872RDF feed
Gene description e26 avian leukemia oncogene 2, 3' domain  +
Gene id 23,872  +
Gene judgment TF Gene  +
Gene symbol ets2  +, AU022856  +, and Ets-2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,156  +
Protein family 1.2 Winged Helix-Turn-Helix/16 Ets Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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