Etv1 14009

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Gene ID: 14009
Gene symbol: etv1
Gene Description: ets variant gene 1
Aliases: ER81; Etsrp81
Human Ortholog Gene ID: [2115]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Ets Domain Family
Homolog Cluster(s): 104156


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12750007] DNA Binding Human Medium Yeast one hybrid screening with the −22 to +6 region of the PS1 promoter produces a clone with a 5′-end identical to ER81 (Etv1). EMSAs with the PS1 promoter fragment indicate ER81 recognizes specifically the −10 region of promoter. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Yeast one hybrid screening and EMSA analyses indicate ER81 specifically recognizes a region of the PS1 promoter. Overexpression of ER81 resulted in a dose-dependent increase in PS1 transcription.

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Facts about Etv1 14009RDF feed
Gene description ets variant gene 1  +
Gene id 14,009  +
Gene judgment TF Gene  +
Gene symbol etv1  +, ER81  +, and Etsrp81  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,156  +
Protein family 1.2 Winged Helix-Turn-Helix/16 Ets Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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