Etv3 27049

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Gene ID: 27049
Gene symbol: etv3
Gene Description: ets variant gene 3
Aliases: AI414410; METS; Pe1
Human Ortholog Gene ID: [2117]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Ets Domain Family
Homolog Cluster(s): 104156

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12007404] DNA Binding Mouse Strong METS specifically binds the ETS recognition element within the c-Myc promoter as shown in EMSA. Results confirmed with ChIP assays in terminally differentiated mouse peritoneal macrophages. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

METS specifically binds the ETS recognition element within the c-Myc promoter as shown in EMSA and ChIP assays. METS represses the c-Myc promoter in transfected CV-1 cells.


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Facts about Etv3 27049RDF feed
Gene description ets variant gene 3  +
Gene id 27,049  +
Gene judgment TF Gene  +
Gene symbol etv3  +, AI414410  +, METS  +, and Pe1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 104,156  +
Protein family 1.2 Winged Helix-Turn-Helix/16 Ets Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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