Evi1 14013

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Gene ID: 14013
Gene symbol: evi1
Gene Description: ecotropic viral integration site 1
Aliases: D630039M04Rik; Evi-1; Jbo
Human Ortholog Gene ID: [2122]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / BetaBetaAlpha-zinc finger Family
Homolog Cluster(s): 107586


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15889140] DNA Binding; Transactivation Unknown Strong DNA Binding; transactivation Jared Roach
Additional Reviewer Comments:
Reviewer: Jared Roach

From OMIM: "The murine Evi1 gene encodes a protein that has multiple 28-amino acid repeats containing the consensus sequence found in the zinc finger domains of many transcriptional regulatory proteins." Also from OMIM: "Buonamici et al. (2004) generated a mouse model of EVI1-positive myelodysplasia by infecting mouse bone marrow cells with an EVI1-expressing retrovirus and transplanting them into lethally irradiated syngeneic recipients. EVI1 induced a fatal disease characterized by severe pancytopenia which did not progress to acute myeloid leukemia. The immediate effects of EVI1 were hyperproliferation of bone marrow cells and downregulation of the genes encoding the receptors for erythropoietin (EPOR; 133171) and thrombopoeitin (MPL; 159530)."

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Facts about Evi1 14013RDF feed
Gene description ecotropic viral integration site 1  +
Gene id 14,013  +
Gene judgment TF Gene  +
Gene symbol evi1  +, D630039M04Rik  +, Evi-1  +, and Jbo  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,586  +
Protein family 2.1 Zinc-coordinating Group/17 BetaBetaAlpha-zinc finger Family  +
Protein group 2.1 Zinc-coordinating Group   +
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