Ezh2 14056

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Gene ID: 14056
Gene symbol: ezh2
Gene Description: enhancer of zeste homolog 2 (drosophila)
Aliases: Enx-1; Enx1h; KIAA4065; MGC90723; mKIAA4065
Human Ortholog Gene ID: [2146]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: non-sequence-specific;

Transcription Factor Binding: tf co-factor binding

DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / No Family Level Classification
Homolog Cluster(s): 14055

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15520282] Non-specific DNA; TF PPI Mouse Strong ChIP assays performed from undifferentiated myoblasts or differentiated myotubes indicate EZH2 binds muscle-specific regulatory regions. Coimmunoprecipitation shows EZH2 interacts with DNA-binding protein YY1. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

ChIP assays indicate EZH2 binds muscle-specific regulatory regions. Coimmunoprecipitation shows EZH2 interacts with DNA-binding protein YY1. Luciferase assay conducted on transfected NIH 3T3 fibroblasts suggests Ezh2 represses muscle gene expression.


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Facts about Ezh2 14056RDF feed
Gene description enhancer of zeste homolog 2 (drosophila)  +
Gene id 14,056  +
Gene judgment TF Gene  +
Gene symbol ezh2  +, Enx-1  +, Enx1h  +, KIAA4065  +, MGC90723  +, and mKIAA4065  +
Gene taxonomy DNA-Binding: non-sequence-specific  +, and Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 14,055  +
Protein family 1.1 Helix-Turn-Helix Group/999 No Family Level Classification  +
Protein group 1.1 Helix-Turn-Helix Group   +
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