Fhl2 14200

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Gene ID: 14200
Gene symbol: fhl2
Gene Description: four and a half lim domains 2
Aliases: C76204; SLIM3
Human Ortholog Gene ID: [2274]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 104360

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10654935] TF PPI Human Strong FHL2 is identified as an AR (androgen receptor) cofactor in a yeast two-hybrid screen. GST pulldown experiments performed using GST�FHL2 and various in vitro translated nuclear receptors shows that FHL2 binds specifically to the full-length AR. Association is confirmed by coimmunoprecipitation from nuclear extracts (293 cells). Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

FHL2 is identified as an AR (androgen receptor) cofactor in a yeast two-hybrid screen. GST pulldown experiments shows that FHL2 binds specifically to the full-length AR. Association is confirmed by coimmunoprecipitation from nuclear extracts. Cotransfection assays in 293 cells show FHL2 acts as a coactivator of AR-dependent transcription.


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Facts about Fhl2 14200RDF feed
Gene description four and a half lim domains 2  +
Gene id 14,200  +
Gene judgment TF Gene  +
Gene symbol fhl2  +, C76204  +, and SLIM3  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 104,360  +
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