Fos 14281

From TFCatWiki

Jump to: navigation, search

External Links

Gene ID: 14281
Gene symbol: fos
Gene Description: fbj osteosarcoma oncogene
Aliases: c-fos; D12Rfj1
Human Ortholog Gene ID: [2353]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[2243767] DNA Binding Mouse Strong Sequence specificity of DNA binding is determioned by selection/amplification experiments. Jaspar Database
[8798512] DNA Binding Human Medium Supershift assays with nuclear extracts from RKO cells indicate Fos binds the AP-1 motif of the u-PAR promoter. Amy Ticoll
[11925568] Transactivation Human; Mouse Medium Transfection assays in mouse neuroblastoma Neuro2A and human glioblastoma U251 cells show c-fos regulates fosB, GluR6 and BDNF expression. Amy Ticoll
[15073183] DNA Binding Mouse Strong ChIP assay with primary wild-type bone marrow cells and Fos-/- splenocytes indicates c-Fos binds to the Nfatc1 and Acp5 promoters. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Supershift assays indicate Fos binds the AP-1 motif of the u-PAR promoter. ChIP assay shows c-Fos binds to the Nfatc1 and Acp5 promoters. Transfection assays show c-fos regulates fosB, GluR6 and BDNF expression.


DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here


The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Fos 14281RDF feed
Gene description fbj osteosarcoma oncogene  +
Gene id 14,281  +
Gene judgment TF Gene  +
Gene symbol fos  +, c-fos  +, and D12Rfj1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
Personal tools