Fosl2 14284

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Gene ID: 14284
Gene symbol: fosl2
Gene Description: fos-like antigen 2
Aliases: Fra-2
Human Ortholog Gene ID: [2355]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Leucine Zipper Family
Homolog Cluster(s): 107503

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[13679379] DNA Binding; Transactivation Human Strong Fra-2 strongly up-regulate endogenous fra-1 mRNA expression in a gene reporter assay.

Fra-2 Binds to the fra-1 Promoter (EMSA and chIP experiments). They use A549 cells, a human alveolar type II-like epithelial cell line.

Elodie Portales-Casamar
[15558021] DNA Binding Mouse Medium Fra-2 binds the uPA enhancer in MEF (EMSA). This binding is less clear in the chIP experiment. Elodie Portales-Casamar
Additional Reviewer Comments:
Reviewer: Elodie Portales-Casamar

Fra-2 is reported in many AP-1 complexes. It binds to AP-1 specific binding site as a dimer and transactivate the transcription of ts targets.


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Facts about Fosl2 14284RDF feed
Gene description fos-like antigen 2  +
Gene id 14,284  +
Gene judgment TF Gene  +
Gene symbol fosl2  +, and Fra-2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,503  +
Protein family 3 Zipper-Type Group/21 Leucine Zipper Family  +
Protein group 3 Zipper-Type Group   +
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