Foxa2 15376

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Gene ID: 15376
Gene symbol: foxa2
Gene Description: forkhead box a2
Aliases: Hnf-3b; HNF3-beta; Hnf3b; HNF3beta; Tcf-3b; Tcf3b
Human Ortholog Gene ID: [3170]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[16847327] DNA Binding Mouse Strong EMSAs with nuclear extract from Beta-TC3 cells indicate FoxA2 binds to the Islet Beta-Cell-Specific mafA promoter. Results confirmed with ChIP assays in Beta-TC3 cells. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

EMSAs and ChIP assays indicate FoxA2 binds to the Islet Beta-Cell-Specific mafA promoter. Transfection assays indicate FoxA2 activates mafA expression in β cells.


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Facts about Foxa2 15376RDF feed
Gene description forkhead box a2  +
Gene id 15,376  +
Gene judgment TF Gene  +
Gene symbol foxa2  +, Hnf-3b  +, HNF3-beta  +, Hnf3b  +, HNF3beta  +, Tcf-3b  +, and Tcf3b  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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