Foxd1 15229

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Gene ID: 15229
Gene symbol: foxd1
Gene Description: forkhead box d1
Aliases: AI385632; BF-2; FREAC4; Hfh10; Hfhbf2
Human Ortholog Gene ID: [2297]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[7957066] DNA Binding Other Medium DNA binding specificity of FKHL8 through selection of high affinity binding sites from random sequence oligonucleotides. Jared Roach
[13678594] DNA Binding; Transactivation Mouse Medium Using ko mice with inducible expressed FoxD1, identify direct target - Placental Growth Factor (PlGF). FoxD1 "binds to a conserved HNF3beta site in the PlGF promoter and activates transcription. PlGF is precisely coexpressed with [FoxD1], both temporally and spatially, within the developing renal stroma, and it is completely absent in [FoxD1] null kidney stroma." Jared Roach
Additional Reviewer Comments:
Reviewer: Jared Roach

From OMIM: "The forkhead genes are transcription factors distinguished by a characteristic 100-amino acid motif that was originally identified in Drosophila (see 164874). Pierrou et al. (1994) identified 7 human genes containing a forkhead domain and designated them forkhead related activators (FREAC) 1 through 7. Northern blot analysis revealed that the FREAC4, or FKHL8, gene is expressed as a 2.1-kb mRNA exclusively in testis and kidney. Pierrou et al. (1994) determined the DNA binding specificity of FKHL8 through selection of high affinity binding sites from random sequence oligonucleotides. Ernstsson et al. (1996) identified the human forkhead gene FREAC4 (FKHL8) as a nearly full-length cDNA and a 5.2-kb genomic fragment. The intronless gene predicts a protein of 465 amino acids with a hyperacidic N-terminal end, a DNA-binding forkhead domain, and a proline- and alanine-rich C-terminal end. The putative promoter region was active as a reporter fusion in the kidney-derived cell lines 293 and COS-7. Cotransfections with plasmids expressing WT1 (607102), WTAR (a mutated form of WT1), p53 (191170), and a mutated form of p53 revealed a complex pattern of regulation, suggesting that FREAC4 may be regulated by these gene products."


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Facts about Foxd1 15229RDF feed
Gene description forkhead box d1  +
Gene id 15,229  +
Gene judgment TF Gene  +
Gene symbol foxd1  +, AI385632  +, BF-2  +, FREAC4  +, Hfh10  +, and Hfhbf2  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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