Foxd4 14237

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Gene ID: 14237
Gene symbol: foxd4
Gene Description: forkhead box d4
Aliases: Fkh2; FREAC5
Human Ortholog Gene ID: [200350]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[7957066] DNA Binding Human Strong Gel shift and DNase footprinting assays indicate FREAC-5 (Foxd4) has a specific DNA binding site. DNA binding specificity is determined through selection of high-affinity binding sites from random sequence oligonucleotides. Amy Ticoll
[15302827] Transactivation Other Medium Fkh2 (Foxd4) is found to regulate the expression of cdc15+ and spo12+ in fission yeast. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Gel shift and DNase footprinting assays indicate FREAC-5 (Foxd4) has a specific DNA binding site. Fkh2 (Foxd4) is found to regulate the expression of cdc15+ and spo12+ in fission yeast.


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Facts about Foxd4 14237RDF feed
Gene description forkhead box d4  +
Gene id 14,237  +
Gene judgment TF Gene  +
Gene symbol foxd4  +, Fkh2  +, and FREAC5  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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