Foxj2 60611

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Gene ID: 60611
Gene symbol: foxj2
Gene Description: forkhead box j2
Aliases: Fhx
Human Ortholog Gene ID: [55810]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10777590] DNA Binding Human Strong Two distinct FOXJ2 consensus binding sites (designated Type A and B) were identified in binding site selection experiments performed using bacterially expresed GST:FOXJ2 fusion proteins. FOXJ2 contacts within the Type B binding site were identified by footprinting.

FOXJ2 activated transcription using reporter constructs containing either 5 copies of the Type A consensus binding site or 4 copies of the Type B site site cloned upstream of a minimal promoter and transfected into Hep3B cells. A Gal4-FOXOJ2 fusion protein displayed constitutive activity following transient transfection into Hep3B cells.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Two distinct FOXJ2 consensus binding sites (designated Type A and B) were identified in binding site selection experiments performed using bacterially expresed GST:FOXJ2 fusion proteins. FOXJ2 contacts within the Type B binding site were identified by footprinting. FOXJ2 activated transcription using reporter constructs containing either 5 copies of the Type A consensus binding site or 4 copies of the Type B site site cloned upstream of a minimal promoter and transfected into Hep3B cells. A Gal4-FOXOJ2 fusion protein displayed constitutive activity following transient transfection into Hep3B cells.


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Facts about Foxj2 60611RDF feed
Gene description forkhead box j2  +
Gene id 60,611  +
Gene judgment TF Gene  +
Gene symbol foxj2  +, and Fhx  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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