Foxk1 17425

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Gene ID: 17425
Gene symbol: foxk1
Gene Description: forkhead box k1
Aliases: A630048H08Rik; AI463295; Mnf
Human Ortholog Gene ID: [221937]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8007964] DNA Binding; Transactivation Human; Mouse Strong DNA binding : based on EMSA with purified protein, binding of MNF to the myoglobin CCAC box is sequence specific.

Transactivation : transfection of the amino-terminal MNF-GAL4 chimera results in 10-fold trans-activation of a beta-galactosidase reporter gene controlled by the GAL1 promoter.

David Martin
[9271401] DNA Binding Human; Mouse Strong DNA binding : shown by EMSA.

Transactivation : promoter-luciferase constructs tend to demonstrate a repressor effect.

David Martin
Additional Reviewer Comments:


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Facts about Foxk1 17425RDF feed
Gene description forkhead box k1  +
Gene id 17,425  +
Gene judgment TF Gene  +
Gene symbol foxk1  +, A630048H08Rik  +, AI463295  +, and Mnf  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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