Foxl2 26927

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Gene ID: 26927
Gene symbol: foxl2
Gene Description: forkhead box l2
Aliases: BPES; Pfrk; PINTO
Human Ortholog Gene ID: [668]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15059956] DNA Binding; Transactivation Mouse Strong Foxl2 tranactivates the human Steroidogenic Acute Regulatory gene promoter (StAR �885-bp) following transient transfection in CHO cells.

Foxl2 binds the StAR promoter in gel shift studies performed using nuclear extracts of CHO cells transfected with the FOXL2 cDNA incubated with a human StAR promoter DNA fragment (�95/+39).

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Foxl2 tranactivates the human Steroidogenic Acute Regulatory gene promoter (StAR –885-bp) following transient transfection in CHO cells. Foxl2 binds the StAR promoter in gel shift studies performed using nuclear extracts of CHO cells transfected with the FOXL2 cDNA incubated with a human StAR promoter DNA fragment (–95/+39).


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Facts about Foxl2 26927RDF feed
Gene description forkhead box l2  +
Gene id 26,927  +
Gene judgment TF Gene  +
Gene symbol foxl2  +, BPES  +, Pfrk  +, and PINTO  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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