Foxo3a 56484

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Gene ID: 56484
Gene symbol: foxo3a
Gene Description: forkhead box o3a
Aliases: 1110048B16Rik; 2010203A17Rik; C76856; Fkhr2; FKHRL1; Foxo3
Human Ortholog Gene ID: [2309]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10102273] DNA Binding; Transactivation Human Strong FOXO3A bound DNA in a gel shift assay performed using oligonucleotides encoding the forkhead binding sites in the IGFBP1 and Fas ligand gene promoters and protein extracts prepared from 293T cells transfectred with a FOXO3a expression vector together with a consitutively active form of Akt. Antibody supershift confirmed the participation of FOXO3a in the retarded complex observed in the gel shift experiments.

FOXO3A transactivates a construct containing the Fas ligand forkhead binding sites following transient cotransfection in CCL39 fibroblasts.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

FOXO3A bound DNA in a gel shift assay performed using oligonucleotides encoding the forkhead binding sites in the IGFBP1 and Fas ligand gene promoters and protein extracts prepared from 293T cells transfectred with a FOXO3a expression vector together with a consitutively active form of Akt. Antibody supershift confirmed the participation of FOXO3a in the retarded complex observed in the gel shift experiments. FOXO3A transactivates a construct containing the Fas ligand forkhead binding sites following transient cotransfection in CCL39 fibroblasts.


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Facts about Foxo3a 56484RDF feed
Gene description forkhead box o3a  +
Gene id 56,484  +
Gene judgment TF Gene  +
Gene symbol foxo3a  +, 1110048B16Rik  +, 2010203A17Rik  +, C76856  +, Fkhr2  +, FKHRL1  +, and Foxo3  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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