Foxo4 54601

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Gene ID: 54601
Gene symbol: foxo4
Gene Description: forkhead box o4
Aliases: afx; Afxh; MGC117660; Mllt7
Human Ortholog Gene ID: [4303]
Reviewer Judgement: TF Gene Candidate
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11777915] DNA Binding; Transactivation Human Strong Co-transfections of AFX expression vector and luciferase reporter containing BCL6 promoter region (with truncations) in 293E cells demonstrate that AFX can transactivate the reporter construct. EMSA using wild-type and mutant AFX DNA-binding domains identifies the S6 site on BCL6 promoter. Alice Chou
Additional Reviewer Comments:
Reviewer: Alice Chou

AFX transactivates a luciferase reporter containing BCL6 promoter region in 293E cells. AFX binds to the S6 site on BCL6 promoter in vitro.

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Facts about Foxo4 54601RDF feed
Gene description forkhead box o4  +
Gene id 54,601  +
Gene judgment TF Gene Candidate  +
Gene symbol foxo4  +, afx  +, Afxh  +, MGC117660  +, and Mllt7  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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