Foxo6 329934

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Gene ID: 329934
Gene symbol: foxo6
Gene Description: forkhead box o6
Aliases:
Human Ortholog Gene ID:
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[12857750] Transactivation Mouse Medium In response to stimulation with insulin-like growth factors, PKB phosphorylates FOXO-proteins. This results in translocation of the forkhead protein from the nucleus to the cytosol. FOXO6 however has a poor translocation rate and remains mostly nuclear (transfection of HEK-293 cells followed by immunolocalization).

FoxO6 transactivates a 6DBE (optimal DAF-16 binding elements) containing luciferase construct.

Elodie Portales-Casamar
[15987244] DNA Binding; Transactivation Mouse Strong FoxO6 binds to specific DNA sequence, the optimal FoxO-binding element (EMSA).

FoxO6 transactivates a wt G-6-Pase promoter-luciferase construct but not when the FoxO-binding element are mutated.

Elodie Portales-Casamar
Additional Reviewer Comments:
Reviewer: Elodie Portales-Casamar

FoxO6 is one of the Forkhead members of the 'O' class (FoxO) of transcription factors. FoxO factors are regulated by insulin which lead to their translocation from the nucleus to the cytoplasm. FoxO6, however, remains mostly nuclear due to the fact that its shuttling ability is dramatically impaired. FoxO6 transcriptional activity is still inhibited by growth factors, but independent of shuttling, through phosphorylation.


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Facts about Foxo6 329934RDF feed
Gene description forkhead box o6  +
Gene id 329,934  +
Gene judgment TF Gene  +
Gene symbol foxo6  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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