Foxp2 114142

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Gene ID: 114142
Gene symbol: foxp2
Gene Description: forkhead box p2
Aliases: 2810043D05Rik; AI449000; CAG-16; D0Kist7
Human Ortholog Gene ID: [93986]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / Forkhead Domain Family
Homolog Cluster(s): 108655

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11358962] Transactivation Human; Mouse Not Selected A transcriptional repressor using cotransfection reporter assays. Tim Hughes
[14701752] DNA Binding; Transactivation Mouse Not Selected This protein has been shown by at least two groups to be a transcriptional repressor using cotransfection reporter assays (PMID: 14701752. The protein binds DNA directly by gel-shift assay. The repression activity requires the binding site to be part of the reporter construct, which demonstrates sequence specificity. Tim Hughes
[11358962] Transactivation Mouse Strong Foxp1 was cloned by screening an adult mouse lung cDNA library under low stringency using a probe derived from the Foxa2 DNA binding domain.

Foxp1 repressed transctiption mediated by the human SP-C (3.7 kb) and CC10 (804 bp) gene promoters following transient cotransfection in H441 and MLE-15 cells.

Rob Sladek
[14701752] DNA Binding; Transactivation Mouse Strong Foxp1 represses activity of the CC10 promoter through recruitment of the corepressor CtBP-1.

Foxp1 binds as a homodimer to a CC10 promoter element (5'-TGAAAAGAGATTATTTGCTTATTCCACGGAGAAGATGACAAGTAAATAATG-3') in gel shift assays performed using protein synthesized in reticulocyte lysates.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Foxp1 was cloned by screening an adult mouse lung cDNA library under low stringency using a probe derived from the Foxa2 DNA binding domain. Foxp1 repressed transctiption mediated by the human SP-C (3.7 kb) and CC10 (804 bp) gene promoters following transient cotransfection in H441 and MLE-15 cells. Foxp1 repression of CC10 promoter activity involves recruitment of the corepressor CtBP-1. Foxp1 binds as a homodimer to a CC10 promoter element (5'-TGAAAAGAGATTATTTGCTTATTCCACGGAGAAGATGACAAGTAAATAATG-3') in gel shift assays performed using protein synthesized in reticulocyte lysates.

Reviewer: Tim Hughes

This protein has been shown by at least two groups to be a transcriptional repressor using cotransfection reporter assays (PMID: 14701752, PMID: 11358962). The protein binds DNA directly by gel-shift assay (PMID: 14701752). The repression activity requires the binding site to be part of the reporter construct, which demonstrates sequence specificity (PMID: 14701752).


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Facts about Foxp2 114142RDF feed
Gene description forkhead box p2  +
Gene id 114,142  +
Gene judgment TF Gene  +
Gene symbol foxp2  +, 2810043D05Rik  +, AI449000  +, CAG-16  +, and D0Kist7  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 108,655  +
Protein family 1.2 Winged Helix-Turn-Helix/102 Forkhead Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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