Gata4 14463

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Gene ID: 14463
Gene symbol: gata4
Gene Description: gata binding protein 4
Aliases: Gata-4
Human Ortholog Gene ID: [2626]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / GATA Domain Family
Homolog Cluster(s): 14460

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8455608] DNA Binding; Transactivation Mouse Strong Gata4 was cloned from a 6.5d mouse embryo library with degenerate oligonucleotide probes directed at a conserved region in the zinc finger domain.

The recombinant Gata4 protein, expressed by transfection in Cos cells, bound to a fragment of the PPET-1 promoter (bases -157 to -114) in gel shift assays.

Gata4 transactivated synthetic promoters containing one and six GATA motifs in transient trasfections of NIH3T3 cells.

Rob Sladek
Additional Reviewer Comments:
Reviewer: Rob Sladek

Gata4 was cloned from a 6.5d mouse embryo library with degenerate oligonucleotide probes directed at a conserved region in the zinc finger domain. The recombinant Gata4 protein, expressed by transfection in Cos cells, bound to a fragment of the PPET-1 promoter (bases -157 to -114) in gel shift assays. Gata4 transactivated synthetic promoters containing one and six GATA motifs in transient trasfections of NIH3T3 cells.


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Facts about Gata4 14463RDF feed
Gene description gata binding protein 4  +
Gene id 14,463  +
Gene judgment TF Gene  +
Gene symbol gata4  +, and Gata-4  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 14,460  +
Protein family 2.1 Zinc-coordinating Group/104 GATA Domain Family  +
Protein group 2.1 Zinc-coordinating Group   +
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