Gtf2i 14886

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Gene ID: 14886
Gene symbol: gtf2i
Gene Description: general transcription factor ii i
Aliases: 6030441I21Rik; BAP-135; GtfII-I; Spin; TFII-I; WBSCR6
Human Ortholog Gene ID: [2969]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Winged Helix-Turn-Helix
DBD Protein Group/Family Classification: Winged Helix-Turn-Helix / GTF2I Domain Family
Homolog Cluster(s): 14886

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8662630] DNA Binding Human Medium EMSAs with extracts from HeLa cells indicate binding of TFII-I (Gtf2i) to the Inr element. Amy Ticoll
[17052463] DNA Binding Mouse Medium ChIP assay with extracts from Swiss 3T3 cells indicates TFII-I (Gtf2i) is recruited to the c-fos promoter. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

ChIP assay shows TFII-I is recruited to the c-fos promoter. EMSAs indicate binding of TFII-I (Gtf2i) to the Inr element. In vitro transcription assays suggest TFII-I (Gtf2i) is essential for TATA-Inr+ transcription.


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Facts about Gtf2i 14886RDF feed
Gene description general transcription factor ii i  +
Gene id 14,886  +
Gene judgment TF Gene  +
Gene symbol gtf2i  +, 6030441I21Rik  +, BAP-135  +, GtfII-I  +, Spin  +, TFII-I  +, and WBSCR6  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 14,886  +
Protein family 1.2 Winged Helix-Turn-Helix/101 GTF2I Domain Family  +
Protein group 1.2 Winged Helix-Turn-Helix   +
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