Ctcf 13018

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Gene ID: 13018
Gene symbol: ctcf
Gene Description: ccctc-binding factor
Aliases: AW108038
Human Ortholog Gene ID: [10664]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / BetaBetaAlpha-zinc finger Family
Homolog Cluster(s): 107586

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[8246978] DNA Binding; Transactivation Other Strong CTCF is purified using sequence-specific chromatography with chicken c-myc 5'-flanking region and checked using EMSA and DNaseI footprinting. Missing-contact probing involving EMSA with mutated oligos is used to find the bases that contact CTCF. CAT reporter construct with wild type and mutated c-myc CTCF binding sites shows that the mutation that eliminates CTCF-binding decrease reporter expression. Andrew Kwon
[15143173] DNA Binding Mouse Strong EMSA with wild type and mutated H19/Igf2 ICR shows that only the wild type binds to the ICR. This binding is competed by unlabeled oligos and supershifted by anti-CTCF Ab. Andrew Kwon
Additional Reviewer Comments:
Reviewer: Andrew Kwon

EMSA, cotransfection, and DNaseI footprinting assay shows that CTCF binds to a specific sequence and activate transcription. CTCF is also involved in imprinting and acts as insulators.


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Facts about Ctcf 13018RDF feed
Gene description ccctc-binding factor  +
Gene id 13,018  +
Gene judgment TF Gene  +
Gene symbol ctcf  +, and AW108038  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 107,586  +
Protein family 2.1 Zinc-coordinating Group/17 BetaBetaAlpha-zinc finger Family  +
Protein group 2.1 Zinc-coordinating Group   +
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