Atoh8 71093

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Gene ID: 71093
Gene symbol: atoh8
Gene Description: atonal homolog 8 (drosophila)
Aliases: 4933425C05Rik; Hath6; Math6; okadin
Human Ortholog Gene ID: [84913]
Reviewer Judgement: TF Gene Candidate
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11921

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[11733035] Other Mouse Weak Math6 is initially expressed by neural precursor cells in the ventricular zone, but later by subsets of differentiating and mature neurones such as hippocampal neurones and cerebellar Purkinje cells. Mis-expression of Math6 with retrovirus in the developing retina induced neurogenesis, while inhibiting gliogenesis, without affecting cell proliferation and death. These results show that cells which would normally differentiate into glia adopted the neuronal fate by mis-expression of Math6, indicating that Math6 promotes neuronal vs. glial fate determination in the nervous system. Wyeth Wasserman
[12419857] Other Human Weak Immunohistochemistry and in situ hybridization confirmed that many flow-responsive genes, including the novel basic helix-loop-helix transcription factor Hath6, are expressed in endothelial cells in vivo. Math6 may bepartially responsible for the establishment and maintenance of the flow-adapted endothelial phenotype in vivo.

EXPRESSION: A single major band of the expected size of 3 kb was detected in highly vascularized tissues, such as heart, lung, liver, and kidney.

No direct study of DNA binding

Wyeth Wasserman
Additional Reviewer Comments:
Reviewer: Wyeth Wasserman

aka Math6 bHLH protein aka Hath6 aka okadin PMID 14872008 refers to a shear-response element, which might be relevant for someone interested in this gene (no evidence that this TF binds to the element) No evidence for sequence-specific binding - all inferred from bHLH domain


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Facts about Atoh8 71093RDF feed
Gene description atonal homolog 8 (drosophila)  +
Gene id 71,093  +
Gene judgment TF Gene Candidate  +
Gene symbol atoh8  +, 4933425C05Rik  +, Hath6  +, Math6  +, and okadin  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,921  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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