Ascc1 69090

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Gene ID: 69090
Gene symbol: ascc1
Gene Description: activating signal cointegrator 1 complex subunit 1
Aliases: 1810015P09Rik; AI550520; ASC1p50; CGI-18
Human Ortholog Gene ID: [51008]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 69090

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10454579] Co-activation Human Strong GST pull-down assays and yeast two-hybrid tests show ASC-1 (Ascc1) binds basal transcription factors TBP and TFIIA, transcription integrators steroid receptor coactivator 1 (SRC-1) and CBP-p300, and nuclear receptors. Indirect immunofluorescence studies indicate ASC-1 can be localized in the nucleus. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

GST pull-down assays and yeast two-hybrid tests show ASC-1 (Ascc1) binds transcription factors including basal factors and nuclear receptors. Indirect immunofluorescence studies indicate ASC-1 can be localized in the nucleus. Cotransfection assays in CV-1 cells suggest ASC-1 is a transcription coactivator of nuclear receptors.


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Facts about Ascc1 69090RDF feed
Gene description activating signal cointegrator 1 complex subunit 1  +
Gene id 69,090  +
Gene judgment TF Gene  +
Gene symbol ascc1  +, 1810015P09Rik  +, AI550520  +, ASC1p50  +, and CGI-18  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 69,090  +
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