Barx1 12022

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Gene ID: 12022
Gene symbol: barx1
Gene Description: barh-like homeobox 1
Human Ortholog Gene ID: [56033]
Reviewer Judgement: TF Gene Candidate
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Helix-Turn-Helix Group
DBD Protein Group/Family Classification: Helix-Turn-Helix Group / Homeodomain Family
Homolog Cluster(s): 103889


Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15809042] Transactivation Mouse Medium Transactivation assays suggest Barx1 is involved in transcription regulation. Jared Roach
[7669690] DNA Binding Mouse Weak In the process of cloning murine proteins capable of binding to a regulatory module of the Ncam promoter, the authors isolated Barx1. Elodie Portales-Casamar
[15809042] Other Mouse Weak Barx1 loss in the mesenchyme prevents stomach epithelial differentiation.

Barx1 directs mesenchymal cell expression of two secreted Wnt antagonists, sFRP1 and sFRP2, and these factors are sufficient replacements for Barx1 function.

Elodie Portales-Casamar
Additional Reviewer Comments:
Reviewer: Jared Roach

No published evidence found showing Barx1 directly binding DNA. Transactivation assays suggest Barx1 is involved in transcription regulation. Barx1 contains a homeobox.

Reviewer: Elodie Portales-Casamar

There is no real evidence of the role of Barx 1 in regulation of transcription itself. One study isolated Barx 1 for its binding to a regulatory module in the NCAM promoter though. Moreover Barx 1 -/- mice show a misregulation of some gene expression during gut organogenesis.

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Facts about Barx1 12022RDF feed
Gene description barh-like homeobox 1  +
Gene id 12,022  +
Gene judgment TF Gene Candidate  +
Gene symbol barx1  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 103,889  +
Protein family 1.1 Helix-Turn-Helix Group/2 Homeodomain Family  +
Protein group 1.1 Helix-Turn-Helix Group   +
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