Bcl3 12051

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Gene ID: 12051
Gene symbol: bcl3
Gene Description: b-cell leukemia/lymphoma 3
Aliases: AI528691; Bcl-3
Human Ortholog Gene ID: [602]
Reviewer Judgement: TF Gene
Functional Classification: Transcription Factor Binding: tf co-factor binding
Homolog Cluster(s): 12051; 109181

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[1501714] TF PPI Other Medium "We show here that the proto-oncogene bcl-3 [...] encodes a protein that functions as an I kappa B-like molecule for native NF-kappa B but is specific for the p50 subunit. The ankyrin repeat domain of the bcl-3 product is shown to mediate complex formation with NF-kappa B dimers by contracting the conserved dimerization domain of NF-kappa B." Jared Roach
Additional Reviewer Comments:
Reviewer: Jared Roach

From the human EntrezGene entry: "This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers." [By Wyeth Wasserman]:A protein subject to interpretation of definition? This co-factor holds a DNA binding TF in the cytoplasm. Limit to candidate status as the protein itself does not enter the nucleus and therefore could be considered a part of the signal transduction pathway. After further reading, it should be listed as TF gene as it directly interacts with a DNA binding TF to repress transcription


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Facts about Bcl3 12051RDF feed
Gene description b-cell leukemia/lymphoma 3  +
Gene id 12,051  +
Gene judgment TF Gene  +
Gene symbol bcl3  +, AI528691  +, and Bcl-3  +
Gene taxonomy Transcription Factor Binding: tf co-factor binding  +
Homolog cluster 12,051  +, and 109,181  +
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