Helt 234219

From TFCatWiki

Jump to: navigation, search

External Links

Gene ID: 234219
Gene symbol: helt
Gene Description: hey-like transcription factor (zebrafish)
Aliases: A830086M02; Hesl; megane; Mgn
Human Ortholog Gene ID: [391723]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 15206

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[14764602] DNA Binding; Transactivation Mouse Not Selected Protein may function in and/or neural differentiation. By EMSA Helt binds E box class B and C1 sequences (but not E box class A) and is not competed by mutated probe, showing specificity. Similar results were obtained by in vitro selection. In reporter cotransfection assays with GAL4 fusion proteins Helt and its Orange domain act as a transcriptional repressor. Tim Hughes
[15071116] Other Mouse Not Selected Encodes a bHLH-like protein that may function in GABAergic neurogenesis. Tim Hughes
Additional Reviewer Comments:
Reviewer: Tim Hughes

This gene (Helt) encodes a bHLH-like protein that may function in GABAergic neurogenesis (PMID: 15071116) and/or neural differentiation (PMID: 14764602). By EMSA Helt binds E box class B and C1 sequences (but not E box class A) and is not competed by mutated probe, showing specificity (PMID: 14764602). Similar results were obtained by in vitro selection (PMID: 14764602). In reporter cotransfection assays with GAL4 fusion proteins Helt and its Orange domain act as a transcriptional repressor (PMID: 14764602).


DISCUSSION PAGE link for this gene

VIEW gene annotation feedback in the [TFCat Annotation Feedback Reports Inquiry]

REPORT gene annotation feedback on the [TFCat Annotation Feedback Reporting System] Help is available here


The section below defines information for semantic searching. Please see the help page for more information on this section.

Facts about Helt 234219RDF feed
Gene description hey-like transcription factor (zebrafish)  +
Gene id 234,219  +
Gene judgment TF Gene  +
Gene symbol helt  +, A830086M02  +, Hesl  +, megane  +, and Mgn  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 15,206  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
Personal tools