Hes3 15207

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Gene ID: 15207
Gene symbol: hes3
Gene Description: hairy and enhancer of split 3 (drosophila)
Aliases: HES-3; MGC144657
Human Ortholog Gene ID: [390992]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 15206

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[10858455] DNA Binding; Transactivation Mouse Strong Hes3 was found to have 2 isoforms. Hes3a was found to be expressed in the postnatal murine cerebellum, while Hes3b was found to be exressed in mouse whole embryos of day 9.5. In EMSA studies, recombinant murine Hes3b bound to N box-containing DNA, while recombinant murine Hes3a did not. In transient cotransfection studies in C3H10T1/2 cells, recombinant murine Hes3b greatly decreased transcription from a luciferase reproter construct that had an N box-containing promoter, while recombinant Hes3a decreased transcription only slightly. Magdalena Swanson
Additional Reviewer Comments:
Reviewer: Magdalena Swanson

Hes3 is a TF. It found to have two isoforms, Hes3a, which was expressed in the postnatal mouse cerebellum, and Hes3b, which was expressed in mouse whole embryos of day 9.5. Recombinant Hes3b bound to N box-containing DNA in EMSA studies and significantly repressed transcription from a luciferase reporter construct in transient cotransfections. Hes3a did not bind N box-containing DNA in EMSA, but it slightly repressed transcription from a luciferase reporter construct in transient cotransfections.


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Facts about Hes3 15207RDF feed
Gene description hairy and enhancer of split 3 (drosophila)  +
Gene id 15,207  +
Gene judgment TF Gene  +
Gene symbol hes3  +, HES-3  +, and MGC144657  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 15,206  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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