Hnf4a 15378

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Gene ID: 15378
Gene symbol: hnf4a
Gene Description: hepatic nuclear factor 4, alpha
Aliases: HNF-4; Hnf4; MODY1; Nr2a1; Tcf14; Tcf4
Human Ortholog Gene ID: [3172]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zinc-coordinating Group
DBD Protein Group/Family Classification: Zinc-coordinating Group / Hormone-nuclear Receptor Family
Homolog Cluster(s): 110784

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[15581617] DNA Binding Mouse Strong Gel shift and ChIP assays indicate HNF4-alpha binds a specific site on the PO proximal promoter. FLOX and KO adult livers cells used for ChIP assays, nuclear extracts from these cells perpared for the EMSAs. Amy Ticoll
Additional Reviewer Comments:
Reviewer: Amy Ticoll

Gel shift and ChIP assays indicate HNF4-alpha binds a specific site on the PO proximal promoter. Transfection assays in CV-1 cells indicate HNF4α activates the PO promoter.


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Facts about Hnf4a 15378RDF feed
Gene description hepatic nuclear factor 4, alpha  +
Gene id 15,378  +
Gene judgment TF Gene  +
Gene symbol hnf4a  +, HNF-4  +, Hnf4  +, MODY1  +, Nr2a1  +, Tcf14  +, and Tcf4  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 110,784  +
Protein family 2.1 Zinc-coordinating Group/18 Hormone-nuclear Receptor Family  +
Protein group 2.1 Zinc-coordinating Group   +
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