Arntl 11865

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Gene ID: 11865
Gene symbol: arntl
Gene Description: aryl hydrocarbon receptor nuclear translocator-like
Aliases: Arnt3; Bmal1; BMAL1b; bmal1b'; MOP3
Human Ortholog Gene ID: [406]
Reviewer Judgement: TF Gene
Functional Classification: DNA-Binding: sequence-specific
DBD Protein Group Classification: Zipper-Type Group
DBD Protein Group/Family Classification: Zipper-Type Group / Helix-Loop-Helix Family
Homolog Cluster(s): 11622; 15206

Evidence:

Pubmed ID Function Species Evidence Strength Reviewer's Comments Reviewer
[9576906] DNA Binding; TF PPI Human Medium Yeast two-hybrid cDNA library screen shows that ARNT1(MOP3)-NPAS2 neuronal PAS domain protein 2 (MOP4) interact. Selection and amplification protocol suggests that the DNA sequence bound by ARNT1-NAPS2 complex is G/TGA/GACACGTGACCC (this sequence is an imperfect palindrome containing a core E-box element). Cotransfection of the above sequence upstream of a minimal simian virus 40 promoter-luciferase reporter into COS-1 cells with MOP3 and MOP4 enhances transcription of reporter gene. Debra Fulton
[9616112] DNA Binding; Transactivation Other; Mouse Strong Yeast one-hybrid DNA-binding assays shows binding of CLOCK-BMAL1 heterodimer to the E-box site from the Drosophila per gene clock control region. Cloned a 2.0-kb fragment of the (mouse) mper1 5' flanking region that includes all three E-boxes for use in luciferase reporter gene assays. CLOCK and BMAL1 together, but not either alone, produced a substantial increase in transcriptional activity - all three E-boxes are potential sites of regulation of mper1 by CLOCK-BMAL1 heterodimers. Debra Fulton
Additional Reviewer Comments:
Reviewer: Debra Fulton

Yeast two-hybrid, yeast one-hybid, and selection amplification assays suggest that ARNT1 forms a complex with other protein partners (NPAS2, CLOCK) and binds e-box motifs. These complexes transactivate reporter genes fused to e-box motif binding domains.


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Facts about Arntl 11865RDF feed
Gene description aryl hydrocarbon receptor nuclear translocator-like  +
Gene id 11,865  +
Gene judgment TF Gene  +
Gene symbol arntl  +, Arnt3  +, Bmal1  +, BMAL1b  +, bmal1b'  +, and MOP3  +
Gene taxonomy DNA-Binding: sequence-specific  +
Homolog cluster 11,622  +, and 15,206  +
Protein family 3 Zipper-Type Group/22 Helix-Loop-Helix Family  +
Protein group 3 Zipper-Type Group   +
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